A conversation on the new science of psychedelic-assisted therapy, set, setting, and the future of mental healthcare.
Oprah Winfrey sits down with Michael Pollan — author of 'How to Change Your Mind' — for a wide-ranging conversation on the new science of psychedelic-assisted therapy.
They discuss the mounting clinical evidence for psilocybin and MDMA in treatment-resistant depression and PTSD, the importance of set and setting, and what changes when you take a substance long pushed to the cultural margins and put it in a clinical container.
Pollan walks through the neuroscience of how these molecules quiet the default mode network — the brain region tied to rumination and rigid self-narratives — and why that matters for healing trauma.
We share this episode because it's one of the clearest mainstream introductions to the field, and because the questions Oprah asks are the same ones our clients arrive at Meadow with.